CARDIOPROTECTIVE EFFECT OF Na/Ca EXCHANGE INHIBITION IN CARDIOPLEGIC ARREST BY SEA0400 by
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Differing cardioprotective efficacy of the Na /Ca exchanger inhibitors SEA0400 and KB-R7943
Magee, William P., Gayatri Deshmukh, Michael P. DeNinno, Jill C. Sutt, Justin G. Chapman, and W. Ross Tracey. Differing cardioprotective efficacy of the Na /Ca2 exchanger inhibitors SEA0400 and KB-R7943. Am J Physiol Heart Circ Physiol 284: H903–H910, 2003. First published November 21, 2002; 10.1152/ajpheart.00784.2002.—KBR7943 and SEA0400 are Na /Ca2 exchanger (NCX) inhibitors with differing p...
متن کاملNa+/H+ exchange inhibition in hypertrophied myocardium subjected to cardioplegic arrest: an effective cardioprotective approach.
OBJECTIVE This study was designed to assess whether the protective effects of Na+/H+ exchange (NHE) inhibition, which have been largely demonstrated in normal hearts, are also manifest in a more surgically relevant model of hypertrophied myocardium subjected to cardioplegic arrest. METHODS Left ventricular hypertrophy was created in 3-week-old rats by coarctation of the ascending thoracic aor...
متن کاملDiffering cardioprotective efficacy of the Na+/Ca2+ exchanger inhibitors SEA0400 and KB-R7943.
KB-R7943 and SEA0400 are Na(+)/Ca(2+) exchanger (NCX) inhibitors with differing potency and selectivity. The cardioprotective efficacy of these NCX inhibitors was examined in isolated rabbit hearts (Langendorff perfused) subjected to regional ischemia (coronary artery ligation) and reperfusion. KB-R7943 and SEA0400 elicited concentration-dependent reductions in infarct size (SEA0400 EC(50): 5.7...
متن کاملThe effects of Na movement on surgical myocardial protection: the role of the Na+-H+ exchange system and Na-channel in the development of ischemia and reperfusion injury.
OBJECTIVES We investigated whether the Na+-H+ exchange inhibitor, HOE642 (Hoe), and/or the Na channel blocker, mexiletine (Mex), enhance a cardioprotective effect on St. Thomas' Hospital cardioplegic solution (STS) to clarify the mechanism by which intracellular Na+ is accumulated after cardioplegic arrest. MATERIALS AND METHODS Isolated working rat hearts were perfused with Krebs-Henseleit b...
متن کاملThe Na+/Ca2+ exchange blocker SEA0400 fails to enhance cytosolic Ca2+ transient and contractility in canine ventricular cardiomyocytes.
AIMS This study was designed to evaluate the effects of the Na(+)/Ca(2+) exchange (NCX) inhibitor SEA0400 on Ca(2+) handling in isolated canine ventricular myocytes. METHODS AND RESULTS Intracellular Ca(2+) ([Ca(2+)](i)) transients, induced by either field stimulation or caffeine flush, were monitored using Ca(2+) indicator dyes. [Ca(2+)](i)-dependent modulation of the inhibitory effect of SE...
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تاریخ انتشار 2013